Bookcase sliding ladder10/12/2023 Employees would unchain the ladder, carefully slide it over a couple feet and then climb up, making sure to chain it again after they’re done.Īnd so, the dream continues unfulfilled. It features sturdy bamboo and refined craft, creating additional space to your home with no harm. All our Quiet Glide Rolling Ladder parts are machined or manufactured by American craftsmen - from the metal work to wood work to the steam-bent handrails. With the Rolling Ladder, it is all about choice. Coastal Driftwood Finish 2 Part Hutch Tall Solid Wood Double Office Library Bookcase With Sliding Ladder 4 Door/Drawer 10 Book Shelf Cabinet (73) FREE shipping Add to Favorites. So the reality of having those ladders would be deeply disappointing for a customer. This Ladder Bookcase adds freshness and aesthetic style to your living space. The Quiet Glide Rolling Library Ladder is a classy way to add functionality to your library, closet, wine cellar, kitchen, pantry, or loft. Wooden Ladder Bookcase, Unassembled and Unfinished Choose Sizes, and Material. Worse, even if it is possible to glide along a bookcase as elegantly as it looks in animation, you couldn’t do that in a crowded bookstore–TBS (To Be Shelved) stacks would be scattered everywhere, customers would be in danger. ![]() ![]() And imagine how sad it would be to walk into a bookstore that is staged to recreate that scene, except that there’s a little chain across the ladder saying “For staff use only”. If it was even possible to install them, they couldn’t be for customer use, for self-evident insurance reasons. ![]() Bookcase With Ladder Awesome Ladder ladder hardware slidingdoor. That’s when I realized the tragic impossibility of the thing. See more ideas about library ladder, best ladder, home addition.
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Authentic al pastor recipe10/12/2023 ![]() After that, baste the meat every 20 minutes for an additional 1 to 1 1/2 hours or until the meat has cooked through. Top with another pineapple slice, and then place on indirect heat for about 1 hour at 350 degrees F. ![]() Then, slowly criss-cross the pork slices, arranging them so that they cover the entire spit in a circle. Use one of these as a bumper, putting it on the spit first. Start by slicing a pineapple into 1/2″ thick circles. TIP: Cool off the marinade to room temperature so it doesn’t cook the meat prematurely. Strain, and then add the sauce back in with the citrus juice and spices. Pack the chiles, onions, and garlic in the blender and blend until smooth. TIP: Heating the whole cumin and oregano seeds for a minute in a hot skillet will bring out the aromatics in each and increase the flavor.Ĭombine the citrus juices (pineapple and orange) with the seasonings, some apple cider vinegar for balance, and the spices – including the Mesquite Seasoning with the ancho powder from our website if you have any – and set it aside. While the water boils, get whole cumin, whole oregano and cinnamon sticks. TIP: Removing the seeds from the chiles before boiling makes the sauce easier to strain later.īoil for about 10 minutes or until those chiles are really plump. I am going to rehydrate these by boiling them for a while in a large pot of water with two onions and two of the biggest garlic cloves I can find. Start by gathering dried cascabel, guajillo and New Mexico chiles. I love the flavor of traditional dried chiles, and we get to use them for this marinade. You can also ask your butcher to do this or purchase pork steaks. TIP: Taking the time to separate the muscles before slicing will increase the tenderness of the finished pork. If the shoulder bone is still inside just slice the bone off the meat and slice the remaining meat into 1/2 inch slices. The pork butt we are using is sliced into 1/2 inch slices and marinated for 12 hours so whatever you don’t fit on the spit can be grilled and served with the rest. Pork butt marinated in a rich red chile based sauce is stacked up on the spit and roasted low and slow until it’s tender and crispy. TIP: If the spit comes with two different size stakes, make sure the one you use can fit under the lid of your grill or smoker. The trompo slowly spins and restaurants cut the meat off of the spit as customers order it, ensuring everyone gets the crispy, caramelized edges. Tacos al Pastor is traditionally made on a ‘trompo” – a large vertical roasting spit that can sometimes hold up to 200 lbs. It’s so delicious that your neighbors are going to come knock on the door and ask what that good smell is, so make extra. Schwarma is a delicious street food, and tacos al pastor was born of the same cooking methods, but with Mexican chiles and spices for flavor. Vertical roasting was brought to Mexico by Lebanese immigrants. ![]() But, the skewer does make for good presentation and easy basting while grilling. The one I’m using you can get herefrom Amazon, but don’t worry – you can also throw the pork directly on the grill. To make these right, you’re going to need a vertical spit. We are fixin’ to have a fiesta today, because I am going to teach you how to make the most tender, juicy, authentic tacos al pastor you can ever imagine. Y’all know how much I love good street food. Howdy, everyone and thanks for joining me in the backyard today. Buy .io domain names10/12/2023 ![]() As the extension was initially intended to be a ccTLD (country-code Top Level Domain), websites operating with the address could’ve fallen prey to unwanted geo-targeting – where your site would only show in country-specific search results. io as a generic Top Level Domain is key to its popularity. io guarantees that you’re keeping hold of vital nuggets of space. nets of this world all use up at least three extra characters. In an SEO infused world, search engines like Google look favourably towards addresses that are as succinct as can be, and while the. io domains provide the shortest website names possible. On the topic of keeping URLs short, the two-character. io would ensure a shorter number of characters in their title thus providing their site with a more recognisable name and and more succinct URL. ![]() While some websites expand on their name by adding words like ’boutique’ or ‘online’ to their business name for the sake of ensuring a vacant. The freedom of choice is essential for users who have already decided on their website name but have grown frustrated by the lack of opportunities to use it in a general Top Level Domain extension. co.uk market, and you can see why the alternative is favoured. io domain extension is how much choice businesses have in picking their name. io?ĭespite its recent boost in popularity, one notable appeal of the. io’s popularity is the potential it carries for ‘domain hacks.’ Because of how many words in the English language end in ‘io’, this TLD enables businesses to make a short and snappy website address – for example or Why use. The extension is also very popular among open source project websites.Īnother key reason for. io websites added relevance in this field. This is because IO, or I/O, is a common abbreviation for input/output – giving. io has emerged as a particularly popular TLD for websites related to computer science. io as non-nation-specific, you do not need to be a resident of the British Indian Ocean Territory to set up a. It’s important to point out that, due to Google’s recognition of. The entire name of the extension must not exceed 256 characters in total. io domain names can range from three and 63 characters long and must contain only alphanumeric characters and hyphens. io has been in existence for over 20 years, with its formation occurring in 1997, and its first registered website arriving a year later – when American clothing company Levi Strauss & Co opened Labels for. This is because “users and webmasters frequently see more generic than country-targeted.”ĭespite representing the British Indian Ocean Territory, the extension has little-to-no relevance to the region itself. ![]() io carrying a country code, it’s regarded by Google as a ‘generic’ Top Level Domain. But few could’ve predicted the popularity of the TLD assigned to the British Indian Ocean Territory, an island area with around 2,500 non-permanent inhabitants, as the extension that would have startups worldwide scrambling to use.io Definitionĭespite. It’s become a craze for new companies to grab themselves a strong alternative website name within a world wide web that’s clogged up with occupied. io represents something of a revolution in the Top Level Domains that are guaranteed to bring exposure. There’s nothing like a fresh new movement to help shake up the old norms and practices of the online real estate game, and. Best music converter youtube10/12/2023 ![]() And the framework includes a vast number of various codecs, both lossy and lossless, that are intended for specific tasks. Though unassuming, it is a part of a well-developed open-source multimedia framework. Media players try to reach as many formats as they can. But even on other systems, compatibility is hardly an issue nowadays. ![]() The stigma on M4A is absent from Apple platforms and devices, as the company proves time after time its dedication to MPEG formats. While the world stubbornly refuses to move on, and a ton of data is still kept in MP3, this "newcomer" offers an objective improvement on the quality to size ratio. The AAC-encoded M4A file is the designated successor to MP3. And how would we rate the best YouTube converter if it didn’t exist? M4A (AAC) On the other hand, if you don’t care about hi-fi sound, it will allow you to pack dozens, if not hundreds of albums on a single SD card. An MP3 can never be restored to its initial quality, so it may be a poor choice for archivists. During compression, some quality is irreversibly lost. When compared to raw audio data, it can reduce file size by a factor of 12. MP3 is both a container file and a compression format. To save yourself time later, read up now. There is no objectively "wrong" format, but depending on your needs, selecting some formats could lead to useless files that don’t fulfill your needs. It’s a matter of compatibility, quality, portability and basically everything else. Lossless or lossy? Open or licensed? Even if you’ve already got a YouTube MP3 converter for Mac or Windows OS, you still have to choose the format. Think carefully before you sign up for this. Remember that there is always a YouTube to MP3 converter Mac free out there. And that’s what you’ll spend for something that you can get cheaper, or even for free. Just keep in mind that over a year, your expenditures will fall slightly short of 144$. But if it’s just a couple videos to kill time in the subway… Well… Maybe the best YouTube to MP3 app can beat it. ![]() Who knows, maybe spending your day watching seminars is a day job - if that’s the case, it even starts sounding like a bargain. What you should consider is how much you actually use YouTube. And over long periods, these twelve bucks could add up to a freaking fortune, inflation notwithstanding. If you’re stingy, it’s hard to justify going from 0 to 12$/month for a service you might not even use all that much. Paying for a service that’s already freely available seems unreasonable. Can it compete with a YouTube to MP3 converter Mac and Windows PC? That makes it worth considering if your Internet connection is not stable.Īnd what’s the other side of the Premium coin? It’s the alternatives. Similar to downloading the files with a YouTube converter to MP3, you will get the ad-free experience, while storing and watching clips to your heart’s content. Quite the price tag! Still, there are a lot of perks you get for the trouble. But does it make sense to pay for it?Ī month of YouTube Premium will cost you $11.99 a month. It also includes the option to download videos and audio for offline consumption, among many other functions. YouTube Premium allows you to watch videos, sans any ads. Antique twin bed rails with hooks10/12/2023 Then you will receive information on the next steps and/or additional information on this policy.ĭue to the increasing demand for a strong center support system capable of attachment to lower-height beds, the bedCLAW No-Sag Center Support System has been developed. To email, your clear images of the issue go to the storefront for our contact information. Transportation charges and a Policy Service Fee are the responsibility of the consumer. Item must be clean and free of stains or damage. Lifetime Policy runs from the original date of purchase and covers the repair of manufacturing defects or replacement of your purchased product. Chinese sellers do not offer such service nor product backing. ![]() and comes with a Lifetime Service Policy. All needed hardware, parts, screws included making this as easy as 1-2-3. The Height Adjustability is continuous from 6-1/2" to 14-3/4", with no missing range. Most customers choose to use 2 or 3 support legs, each installed in the center of a wood slat along the length of the bed.Įach bedCLAW Unibody leg comes with 2 adjustable height glides, along with the adjustable extenders provide you the ability to tailor the bedCLAW Unibody support to a wider range of heights when compared to other less useful support legs. How Many Should I Install? You may install as few or as many as you prefer. We are constantly working to improve our products and bring even better value to our customers. It will protect both carpet and hard floors. No rivets are employed it is made from a single piece of steel that has been formed and welded. The NEW bedCLAW Unibody Adjustable Height Bed Slat Support Leg: The bedCLAW new leg features strong, one-piece unibody construction. Beds utilizing wood slats for support need added legs in the middle to prevent bowing and cracking of the slats because wood naturally changes over time. Wood Bed Support Slats Need Center Support Also: Many beds still use the wood slat method for supporting the mattress/foundation unit. Most mattress manufacturers require center support for their warranty to be valid. ![]() A Center Support supports your foundation unit and mattress in the middle, thus reducing stress on those units. ![]() The Benefits of a Center Support System: All beds, especially those Queen Size and larger, will benefit from the center support and bed support slat system. Best compression socks for long drives10/12/2023 ![]() ![]() And in compression socks, this is classified by the pressure applied at the level of the ankle.Īccording to Derrick, medical-grade compression socks rate as 20-40 mmHg whereas a standard pair - or what an athlete would likely be using - is 15-20 mmHg. This number is used to measure the pressure in the blood vessels. A unit of pressure, mmHg is the reading that a blood pressure cuff gives on its gauge. Compression socks are graded in mmHg, or millimeters of mercury. A 2020 systematic review on compression socks and exercise performance noted that studies suggested compression socks lower muscle fatigue when worn after exercise.Ĭompression socks can either be medical grade (often recommended by a doctor) or standard. YS Robert Kim, M.D., F.A.C.S., and a vascular surgeon at Northwest Vein & Aesthetic Center, said that compression socks support vein health, prevent swelling and improve circulation. When worn for recovery after a workout, compression socks can help fatigued legs by getting blood to the foot faster. “It is going to hasten - or give it a boost - up to the heart so you have a return of that blood to be reoxygenated in the lungs more swiftly and pumped back out to the muscles.” “If you wear the compression sock when exercising, you are going to reduce the work,” Derrick said. She likened the circulatory system to an elevator, which is working harder when having to work against gravity to return blood from the foot up to the heart. While arteries deliver oxygenated blood to the muscles, veins are responsible for returning that blood to the heart to be recirculated throughout the body. ![]() This positive effect was also suggested in the results of a small-scale study on male basketball players, published in a 2020 issue of the Journal of Sport and Health Science, which concluded that markers of “muscle blood flow, and muscle oxygenation are increased with sports compression garments.”ĭerrick said that in order to understand these benefits, it’s important to know that veins and arteries are different. When worn during exercise, compression socks can improve the flow of oxygenated blood throughout the body, which can result in more muscular energy and stamina, Derrick said. Though, in order for compression socks to provide physiological benefits, the sock must extend from the ball of your foot to mid-calf (covering the foot and ankle), said Ellen Derrick, M.D., MP.H., F.A.C.S., F.S.V.S., a vascular surgeon and founder of BoxBar Vascular. With so many compression socks out there, it's hard to choose the best pair for you, so we rounded up the best ones according to reviews from real nurses.From an athletic standpoint, these special sleeves or socks can be worn to increase blood flow in the arms, legs or knees while running. Stretchy, moisture-wicking fabrics like nylon and Spandex can also help keep your feet dry for hours. Nurses need comfortable, slip-resistant pairs so you can move quickly and freely when there's a code blue. "I usually recommend a lighter compression, like 10 to 15 or 15 to 20, to begin with, and for more moderate to severe swelling, we start to go up in numbers, such as 20 to 30 or 30 to 40, which should be a custom fit and prescribed by a doctor," Priya Parthasarathy, D.P.M., a podiatrist based in Silver Spring, MD, and spokesperson for the American Podiatric Medical Association (APMA), said in a previous interview with Prevention. It's best to consult your doctor to figure out the best pressure rating for you, but generally, going lighter is the best way to start. ![]() On the other hand, a firm compression rating has a range of 20 to 30 mmHg. A light pressure rating is anything between 10 and 20 mmHg, while a mild pressure rating is 15 to 20 mmHg. Compression socks have a pressure rating of light, mild, and heavy. In case you're not familiar with how compression socks are designed, the pressure in them is measured in millimeters of mercury (mmHg). How to shop for the best compression socks for nurses But nurses, waiters, mail carriers, and other workers who stand for long shifts can develop pain in their calves and heels from being on their feet all day, so wearing compression socks can help with recovery. Athletes, pregnant women, and people who travel a lot can benefit from using compression socks because they help pump oxygen to damaged muscle tissues, helping them repair faster. If tired muscles and swollen feet are cramping your style, compression socks work to reduce fluid build-up and fatigue in your legs by promoting better blood flow in the veins of the calves and feet. 2021 mtn dew voodew10/11/2023 This flavor was the fifth Halloween-themed flavor to release, the first being Pitch Black (2004), the second being Pitch Black II (2005), the third being VooDEW (2019), the fourth being VooDEW (2020), the sixth being VooDEW (2022), the seventh being VooDEW (2023), and the eighth being VooDEW (2024).It was available in the online DEW Store, Walmart, and Amazon for a limited time while supplies last in fall 2022. On June 3rd, 2022, an anonymous PepsiCo employee stated that three VooDEW flavors would be releasing as a variety 16-ounce can six-pack, two cans of 2019, three cans of 2020, and one can of 2021 as the Ghosts of VooDEW Past. It was officially released in stores in late August 2021, throughout the United States for a limited time in 12-packs and 20-ounce bottles until October 31st, 2021, the end of Halloween 2021, where after that, VooDEW (2022) would succeed it in 2022. This pre-release box contained promotional art and an early sample bottle. In addition, there was also a box sent out exclusively to select Dew Nation HQ members. In August 2021, some test bottles sent out to a few select people, with having differing opinions on the flavor. They described it as a "Generic sweet candy flavor," unable to figure it out. On April 16th, 2021, in a r/MountainDew now-deleted Reddit post, a user named u/AdmiralOink4 posted an image of a bottle of VooDEW (2021). History 2021 Limited Time retail release On October 31st, 2021, VooDewGrim, endorsed by the official Mountain Dew Twitter account, unveiled VooDEW's 2021 Mystery Flavor to be Fruit Candy Chews. Wiesc," 2 of the words that would make sense are "Citrus" and "Fruits," but the book cover already gave that away." ![]() One deleted comment on the post stated "If you use an anagram solver for "Ruth F. They said that the book they're reading is a fascinating read by Ruth F. ![]() One of these clues is from the VooDewGrim Twitter account reading a book. Since this VooDEW flavor was a Mystery Flavor, many people who have tried it have drawn comparisons to Starburst, Laffy Taffy, SweeTARTS, and numerous other fruit candies. ![]() VooDEW (2021) was a Mystery Flavor of Mountain Dew and had a white look with a similar theme to Mountain Dew's other Halloween flavors. Astronomy picture10/11/2023 ![]() K2-18 b might not be able to support life. “The possibility of DMS in the atmosphere is highly promising, but we are planning to take another look to robustly establish its presence.” The James Webb Space Telescope. ![]() “More observations are needed to determine whether it is in fact DMS that we’re seeing,” said Prof Madhusudhan. The abundance of methane and carbon dioxide – and lack of ammonia – is indicative of an ocean beneath a hydrogen-rich atmosphere, but the findings on DMS are less certain. “Traditionally, the search for life on exoplanets has focused primarily on rocky planets, but Hycean worlds are significantly more conducive to atmospheric observations.” “Our findings underscore the importance of considering diverse habitable environments in the search for life elsewhere,” said Prof Madhusudhan. This means our work here is but an early demonstration of what Webb can observe in habitable zone exoplanets.”Įxoplanets such as K2-18 b, which are of sizes between that of Earth and Neptune, are unlike anything in our solar system and remain poorly understood. “For comparison, one transit observation with Webb provided comparable precision to eight observations with Hubble conducted over a few years in a shorter wavelength range.”Ĭo-author Savvas Constantinou, also from Cambridge’s Institute of Astronomy, added: “These results are the product of just two observations of K2-18 b, with many more on the way. “This result was only possible because of the extended wavelength range and unprecedented sensitivity of Webb, which enabled robust detection of spectral features with just two transits,” said Prof Madhusudhan, lead author of a paper being published in The Astrophysical Journal Letters The Astrophysical Journal Letters. During these transits, a tiny fraction of starlight passes through the exoplanet’s atmosphere before reaching Earth, leaving a trace in the stellar spectrum that astronomers can examine. Android file transfer mac10/11/2023
Consensus splice site10/11/2023 ![]() Once the 5′SS is synthesized, the U1 snRNA base pairs with the 5′SS and remains tethered to pol II. Our findings suggest the following model for co-transcriptional splicing: The U1 snRNP associates with elongating pol II during transcription. To interrogate this mechanism, we developed a CRISPR interference-based assay that enables the analysis of factors located over particular DNA regions that are associated with particular regions of the pre-mRNA. However, the mechanism that brings the two splice sites into proximity to facilitate co-transcriptional splicing is unknown. This implies that the formation of the commitment complex occurs almost instantly following the synthesis of the 3′SS. Intron lengthening was accompanied by only a minor compromise in splicing efficiency 25, 27, 28: In mammalian cells, short and long introns are generally spliced rapidly irrespective of length 23, 28. During vertebrate evolution introns lengthened by thousands of nucleotides, whereas the average exon length has remained about 150 nucleotides 25, 26. The 5′SS and the PPT interact with U1 snRNP and U2AF2, respectively, immediately after emerging from within pol II 18, 19.Ī study of splicing kinetics revealed that a large fraction of intron removal is complete within seconds 20, 21 to several minutes in living cells 13, 22, 23, 24. U1 snRNP and U2AF2 associate with the pol II CTD, and these interactions have functional effects on splicing 16, 17. The C-terminal domain (CTD) of pol II is necessary for activation of transcription and for efficient pre-mRNA processing 14, 15. This is termed co-transcriptional splicing. Recent studies indicate that most pre-mRNAs undergo splicing while being transcribed by RNA polymerase II (pol II) 9, 10, 11, 12, although there are exceptions 13. The commitment complex then advances into the pre-spliceosome (complexes A and B), which transitions to other complexes that catalyze intron removal and exon ligation in two steps (complex C) 6. Both splice sites are thus defined at this early stage of the reaction. In this complex, the U1 snRNP binds the 5′SS via base pairing between U1 snRNA and the 5′SS, and the 3′SS and the PPT are associated with a heterodimer of U2AF1 (U2AF35) and U2AF2 (U2AF65) 7, 8. The first step in spliceosome assembly is the formation of the commitment complex. The PPT and the branch site are located upstream of intronic 3′ ends 6. The splicing reaction is governed by four main regulatory consensus sequences: the 5′ and the 3′ splice sites (5′SS and 3′SS, respectively), which are located at exon–intron boundaries, the polypyrimidine tract (PPT), and the branch site sequence. Splicing is carried out within the spliceosome, a multi-component complex composed of five nuclear ribonucleoprotein (snRNP) complexes-U1, U2, U4, U5, and U6-and many additional proteins 4, 5. The splicing machinery recognizes either exons or introns as the spliced unit, through mechanisms called exon definition and intron definition, respectively 3. Splicing is the mRNA maturation reaction where introns are removed from pre-mRNA and exons are ligated together 1, 2. AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |